Retatrutide: Research Uses, Reconstitution, and Safe Laboratory Handling
Reviewed by the VendPeptides Editorial Team. Written from product labeling, the batch certificate of analysis and published literature. Last updated September 2026.
Retatrutide is a synthetic triple-agonist research peptide supplied as a lyophilized powder for laboratory use only.
Retatrutide has been studied in published preclinical and clinical research as a GLP-1/GIP/glucagon receptor triple agonist, including a phase 2 trial reported in NEJM.
It is also catalogued as LY3437943 and GGG tri-agonist (CAS 2381089-83-2), and VendPeptides sells it as single vials and 10-vial bulk kits in 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg strengths.
This guide covers what Retatrutide is, how to calculate reconstitution concentrations by vial size, safe laboratory handling, and where to buy research-grade Retatrutide with a batch certificate of analysis.
What is Retatrutide?
Retatrutide is a lyophilized research peptide classified as a GLP-1/GIP/glucagon receptor triple agonist, with CAS number 2381089-83-2 and the research alias LY3437943.
In the published literature it has been studied as a multi-receptor agonist in metabolic research models; the phase 2 trial by Jastreboff et al. (NEJM 2023) reported its clinical research profile.
VendPeptides supplies Retatrutide as a powder for reconstitution in the laboratory, in single vials and 10-vial bulk kits ranging from 5 mg to 60 mg per vial.
For research purposes only. Not for human consumption.
Retatrutide, LY3437943 and GGG tri-agonist: are they the same?
Yes. LY3437943, GGG tri-agonist, and triple agonist are research aliases for the same molecule, Retatrutide, and all refer to CAS 2381089-83-2.
The alias LY3437943 is the code name used in the published trial literature and on ClinicalTrials.gov study records, while GGG tri-agonist describes its GLP-1/GIP/glucagon receptor activity.
When comparing catalogues or certificates of analysis, match the CAS number and the batch COA rather than relying on the alias alone.
For research purposes only. Not for human consumption.
What has Retatrutide been studied for?
Retatrutide has been studied in published research as a GLP-1/GIP/glucagon receptor triple agonist, including a phase 2 trial reported in NEJM and registered studies listed on ClinicalTrials.gov.
Published work describes receptor binding and metabolic signaling in research models; it does not establish any use outside the laboratory.
As sold by VendPeptides, Retatrutide is not approved for any medical or veterinary purpose, and it is not for human or veterinary use.
For research purposes only. Not for human consumption.
Readers should defer to the published literature for study design details and to the batch certificate of analysis (COA) and vial label for identity, purity, and handling information.
Retatrutide reconstitution and concentration by vial size
Adding 1 mL (1,000 µL) of bacteriostatic water to a 5 mg vial gives 5 mg/mL, and the same math scales to every strength sold.
| Vial size | 10-vial kit total | Diluent added | Resulting concentration | µg per µL |
|---|---|---|---|---|
| 5 mg | 50 mg | 1 mL (1,000 µL) | 5 mg/mL | 5 µg/µL |
| 10 mg | 100 mg | 2 mL (2,000 µL) | 5 mg/mL | 5 µg/µL |
| 15 mg | 150 mg | 3 mL (3,000 µL) | 5 mg/mL | 5 µg/µL |
| 20 mg | 200 mg | 2 mL (2,000 µL) | 10 mg/mL | 10 µg/µL |
| 30 mg | 300 mg | 3 mL (3,000 µL) | 10 mg/mL | 10 µg/µL |
| 40 mg | 400 mg | 2 mL (2,000 µL) | 20 mg/mL | 20 µg/µL |
| 50 mg | 500 mg | 2.5 mL (2,500 µL) | 20 mg/mL | 20 µg/µL |
| 60 mg | 600 mg | 3 mL (3,000 µL) | 20 mg/mL | 20 µg/µL |
The vial label and the batch certificate of analysis take priority over any table; if they differ, follow the label and COA.
Retatrutide 10mg vial reconstitution
Adding 2 mL (2,000 µL) of bacteriostatic water to a 10 mg Retatrutide vial gives 5 mg/mL, or 5 µg/µL.
Swirl gently; do not vortex or shake, and let the powder dissolve fully before recording the final volume.
For research purposes only. Not for human consumption.
Retatrutide 5mg vial reconstitution
Adding 1 mL (1,000 µL) of bacteriostatic water to a 5 mg Retatrutide vial gives 5 mg/mL, or 5 µg/µL.
A larger diluent volume, such as 2 mL, gives 2.5 mg/mL and may suit assays that need a more dilute working stock.
Record the diluent volume and date on the vial label, and cross-check against the batch COA.
How long does reconstituted Retatrutide stay stable?
Stability depends on the diluent, storage temperature, and handling, so the batch COA and vial label are the primary references.
In general laboratory practice, reconstituted peptide solutions are kept refrigerated and protected from light, with freeze-thaw cycles minimized.
See Peptide Storage Guide: Temperature, Light and Freeze-Thaw for storage detail, and How to Reconstitute Lyophilized Peptides: A Laboratory Protocol for the full technique.
How to handle Retatrutide safely in the laboratory
- Put on a lab coat, nitrile gloves, and eye protection before opening the vial.
- Work in a clean, designated area and wipe the surface and the vial septum with 70% isopropyl alcohol.
- Reconstitute with bacteriostatic water or the diluent specified on the vial label, adding the liquid slowly down the inside wall of the vial.
- Swirl gently until the powder is fully dissolved, and never vortex or shake the vial.
- Label the vial with the compound name, concentration, diluent, date, and your initials.
- Store the lyophilized or reconstituted material per the batch COA, typically refrigerated and protected from light.
- Dispose of all materials in the appropriate laboratory waste stream and clean the work surface afterward.
Warning: Contamination and mislabeling are the main laboratory risks; use sterile technique, keep vials capped, and never rely on an unlabeled or unverified vial.
Is Retatrutide the same as Tirzepatide?
No. Retatrutide is a GLP-1/GIP/glucagon receptor triple agonist (CAS 2381089-83-2), while Tirzepatide is a dual GLP-1/GIP receptor agonist, so they differ in receptor activity and structure.
Both are research peptides supplied as lyophilized powders, but they are distinct molecules with separate CAS numbers and separate certificates of analysis.
For a structural and pharmacological comparison, see Tirzepatide vs Semaglutide: Structural and Pharmacological Differences.
For research purposes only. Not for human consumption.
Is Retatrutide safe for humans?
No. Retatrutide from VendPeptides is sold for research purposes only, is not for human consumption, and is not approved for any medical or veterinary purpose.
FDA guidance treats research chemicals as laboratory materials that must be labeled 'not for human consumption'; they are not consumer products.
No safety, medical, or veterinary claims are made here; consult the published literature and the batch COA for research context.
For research purposes only. Not for human consumption.
Can Retatrutide be used for pets or animals?
No. Retatrutide is a research-use-only chemical and is not a veterinary product; it is not approved for any veterinary purpose.
It must not be given to pets, livestock, or any other animal, and it is not for human consumption.
For any animal health question, consult a licensed veterinarian.
For research purposes only. Not for human consumption.
Where to buy Retatrutide (5 mg to 60 mg)
VendPeptides supplies Retatrutide as a single vial or a 10-vial bulk kit in 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg strengths, shipped from a US warehouse.
Every vial carries a batch certificate of analysis (COA) and an expiry date on the label; verify the batch number against the COA before use.
Single vials run from $45.00 (5 mg) to $245.00 (60 mg), while 10-vial kits run from $380.00 (5 mg kit, 50 mg total) to $1,500.00 (60 mg kit, 600 mg total).
Shop the full Metabolic Research Peptides collection, or compare with the Tirzepatide 10-Vial Bulk Kit TR and the Semaglutide 10-Pack Kits SM.
Order Retatrutide as a Retatrutide Single Vial or a Retatrutide 10-Vial Bulk Kit RT.
For research purposes only. Not for human consumption.
Frequently asked questions
Is Retatrutide safe for humans?
No. It is sold for research purposes only and is not for human consumption; it is not approved for any medical or veterinary purpose. Follow the vial label and batch COA for laboratory handling.
Is Retatrutide the same as Tirzepatide?
No. Retatrutide is a GLP-1/GIP/glucagon triple agonist, while Tirzepatide is a dual GLP-1/GIP agonist; they are distinct molecules with different CAS numbers. See the batch COA for identity confirmation.
How do I reconstitute a 10 mg Retatrutide vial?
Add 2 mL (2,000 µL) of bacteriostatic water to a 10 mg vial to get 5 mg/mL, or 5 µg/µL. Swirl gently, do not vortex, and record the volume on the label.
Can Retatrutide be used for pets or animals?
No. It is research-use-only and not a veterinary product; it is not approved for any veterinary purpose. Consult a licensed veterinarian for any animal health question.
Is Retatrutide the same as LY3437943?
Yes. LY3437943 is the research code name for Retatrutide, the same molecule listed under CAS 2381089-83-2. Match the CAS and batch COA when comparing suppliers.
Is Retatrutide a peptide, and what class is it?
Yes. Retatrutide is a synthetic peptide classified as a GLP-1/GIP/glucagon receptor triple agonist. Published research describes its receptor activity in laboratory and clinical research settings.
Can you still buy Retatrutide?
Yes. VendPeptides sells Retatrutide as single vials and 10-vial bulk kits from 5 mg to 60 mg, shipped from a US warehouse with a batch COA and expiry on every label. For research purposes only; not for human consumption.
Sources and further reading
- Jastreboff AM et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. NEJM 2023.
- ClinicalTrials.gov — Retatrutide (LY3437943) studies
- PubChem — Retatrutide
Disclaimer. This article is educational and describes laboratory handling and published literature only. It is not medical or veterinary advice and is not a substitute for a licensed professional. For research purposes only. Not for human consumption. Products are sold to qualified researchers for in-vitro and laboratory research, are not approved drugs, foods, cosmetics or devices, and are not for human or animal use. This article was written with AI assistance and reviewed by a member of the VendPeptides Editorial Team.